An evaluation of p16INK4a expression in cervical intraepithelial neoplasia specimens, including women with HIV-1
نویسندگان
چکیده
منابع مشابه
An evaluation of p16(INK4a) expression in cervical intraepithelial neoplasia specimens, including women with HIV-1.
Although several studies have evaluated the role of p16(INK4a) as a diagnostic marker of cervical intraepithelial neoplasia (CIN) and its association with disease progression, studies regarding the role of p16(INK4a) in human immunodeficiency virus (HIV)-infected patients remain scarce. The present study was designed to determine the potential utility of p16(INK4a) as a diagnostic marker for CI...
متن کاملAn evaluation of p16 expression in cervical intraepithelial neoplasia specimens, including women with HIV-1
P16INK4a is a cyclin-dependent kinase inhibitor that regulates the transition from the G1 to S phase and negatively influences cell proliferation in conjunction with other tumour suppressor proteins, such as the retinoblastoma gene (pRb) (Tringler et al. 2004). As pRb is functionally inactivated by the high-risk human papilloma virus (HPV) oncoprotein E7, there is a concomitant overexpression o...
متن کاملp16INK4A expression in cervical intraepithelial neoplasia and cervical cancer
Introduction: Cervical cancer is the third most common cancer among women and is more common in developing countries such as India, due to lack of good screening tests. The efficacy of the Pap smear is hampered by high inter-observer variability and high false positive and false negative rates. Liquid based cytology has not been shown to improve sensitivity or specificity when compared to Pap s...
متن کاملEvaluation of P16INK4A as a Biomarker in Cervical Intraepithelial Neoplasia
Introduction: Cervical screening would benefit from a test based on a disease-specific biomarker that identifies high grade lesions, which could also indicate the presence of early precancerous lesions that have a high risk of progression to cancer. One such potential biomarker is p16INK4A. Objective of the study was to study the biomarker p16INK4A expression by immunostaining in cervical intra...
متن کاملCervical intraepithelial neoplasia in postmenopausal women with negative cervical cytology.
Cervical intraepithelial neoplasia in postmenopausal women with negative cervical cytology Four cases of cervical intraepithelial neoplasia were detected among 50 postmenopausal women in whom cytological examination of a cervical smear yielded negative results, indicating the need for cytological surveillance of women into old age. Cytological and colposcopic examination of the cervix was perfo...
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ژورنال
عنوان ژورنال: Memórias do Instituto Oswaldo Cruz
سال: 2012
ISSN: 0074-0276
DOI: 10.1590/s0074-02762012000500001